This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y. |
References |
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Cancer Res. 2012 Sep 15;72(18):4744-52. Cytoskeleton (Hoboken). 2011 Mar;68(3):175-87. |
Specification | |
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Entrez GeneID | 81027 |
Swissprot | Q9H4B7 |
clone | 2A1A9 |
WB Predicted band size | 50.3kDa |
Host/Isotype | Mouse IgG1 |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Monkey,Rat |
Immunogen | Purified recombinant fragment of human TUBB1 (AA: 33-166) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |