This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. |
References |
---|
1.Exp Dermatol. 2011 Mar;20(3):273-7. 2.Thromb Haemost. 2011 Jan;105(1):72-80. |
Specification | |
---|---|
Aliases | RIG; REIC |
Entrez GeneID | 27122 |
Swissprot | Q9UBP4 |
clone | 8A5C6 |
WB Predicted band size | 38.3kDa |
Host/Isotype | Mouse IgG1 |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human DKK3 (AA: 91-350 ) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |