The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. |
References |
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1. Cell Signal. 2009 Dec;21(12):1935-44. 2. Nat Struct Mol Biol. 2009 Sep;16(9):945-52. |
Specification | |
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Aliases | IL-1; IL1F2; IL1-BETA |
Entrez GeneID | 3553 |
Swissprot | P01584 |
clone | 3A6 |
WB Predicted band size | 31kDa |
Host/Isotype | Mouse IgG1 |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen |
Purified recombinant fragment of human IL1B expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |