This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. |
References |
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1. J Biol Chem. 2007 Mar 16;282(11):8545-56. 2. Mol Cell Biochem. 2007 Aug;302(1-2):19-26. 3. Urol Oncol. 2010 Mar-Apr;28(2):180-8. |
Specification | |
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Aliases | CDHN; NCAD; CD325; CDw325; CDH2 |
Entrez GeneID | 1000 |
Swissprot | P19022 |
clone | 5D5 |
WB Predicted band size | 99.8kDa |
Host/Isotype | Mouse IgG1 |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | Purified recombinant fragment of human CDH2 expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |