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| CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lym- phocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabo- lites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance. |
| References |
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1. Trends Biochem Sci. 1992 Dec;17(12):495. 2. J Cell Biol. 1999 Sep 6;146(5):1161-72. 3. Exp Hematol. 2002 Jun;30(6):582-9. 4. Mol Immunol. 2006 Mar;43(7):1029-39. |
| Specification | |
|---|---|
| Aliases | T10; CD38 |
| Entrez GeneID | 952 |
| Swissprot | P28907 |
| clone | 6E12D4A12 |
| WB Predicted band size | 34kDa |
| Host/Isotype | Mouse IgG1 |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD38 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
